Large animal models to drive pre-clinical translational research - the pig symposium (2024)
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Welcome to: Large animal models to drive pre-clinical translational research - the pig symposium ...
Welcome to: Large animal models to drive pre-clinical translational research - the pig symposium (2024)
Program: BEN
Description: In recent years, there has been a scientific push to develop translational preclinical large animal models that can bridge the gap between animal studies and human clinical trials. While the use of live animals should be replaced wherever possible, animal models are still necessary to generate data in support of conducting human clinical trials. Among these models, pigs have gained significant attention due to their similarities to humans in terms of proteomics, genomics, and immunology. Pigs, along with other large animal species such as sheep and goats, have been successfully utilized in various fields of medical research, including cardiovascular, respiratory, gastrointestinal, immune, musculoskeletal, neurological, and cancer studies. Importantly, pigs satisfy the evaluation requirements set by regulatory bodies, such as the Food and Drug Administration (FDA), for pharmaceutical drugs.
The anatomical and physiological similarities shared between pigs and humans enable the application of anesthetic techniques, drug administration methods, advanced imaging technologies, translational Omics biomarker studies and surgical procedures that closely resemble those used in human patients. By utilizing pigs as an intermediary step as much superior model compared to rodents, researchers hope to improve the translational efficacy of preclinical evaluations, leading to the development of more effective therapies with enhanced efficacy and reduced adverse effects. The potential for translational data generated from these models to overcome the limitations of rodent models and facilitate advancements in understanding and treating various disease conditions is promising.
This symposium will focus on presenting recent advances in the use of pigs as a large animal model to drive pre-clinical translational research.
Themes for 2024
- Translational models
- New applications
Literature/Requirements: A series of journal papers that will be provided -- TBD
Prerequisites: None – experience with or interest with animal experimental science may be an advantage
Evaluation:
Written.
A list of papers and associated questions will be made available by the speakers.
The student should pick 3 papers/questions and address these in a written report (3 pages maximum)
The written report is due Thursday June 27th
Time is allocated on day 2 of the program in the afternoon to work on the written report.
Dates:
Wednesday June 12 Aalborg University, Selma Lagerløfs Vej 249, 9260 Gistrup, room 12.02.066, 8.30am-17pm NB: New room!
Thursday June 13th Dept. of Pathology, Aalborg University Hospital, Ladegårdsgade 12, 9000 Aalborg, 8.30-16 pm
WEDNESDAY JUNE 12 - SLV, AAU
Title
Speaker
Affilliation
8.30-10.00
Pig models in opthamology
Dept. Of Clinical Medicine, Aalborg University Hospital
Piglet models for neonate research
Dept. Of Veterinary and Animal Sciences, Copenhagen University
MultiOMICs in translational clinical research - a key immunological role for the pig
Dept. of Health Science and Technology, Aalborg University
Coffe
10.30-11.30
Leveraging electrophysiological approaches from rodents in pigs: exploring translational possibilities
Lundbeck A/S
Why Pigs are Promising Models for Developing Neural Interfaces
Dept. of Health Science and Technology, Aalborg University
Lunch
12.30-14.00
Post operative pain: from humans to pigs and back to humans
mdbiosciences, Israel
Behavioural testing
Dept. of Animal and Veterinary Scinces, Aarhus University
Neuropathic pain in pigs – translational perspectives on electrophysiology and behavioral analysis
Dept. of Health Science and Technology, Aalborg University
Coffe
14.30-16.00
Intracerebral pharmacokinetics in pigs
Dept. Of Clinical Medicine, AAU
Principles of stereotaxic surgery in large animal model
Dept. Clinical Medicine, Dept. Of Neurosurgery, Aarhus University
Advantages and disadvantages of large animal models of stroke
Dept. of Health Science and Technology, Aalborg University
16.00-17.00
Labtour
Dept. of Health Science and Technology, Aalborg University
THURSDAY JUNE 13 - LADEGÅRDSGADE
8.30-12.00
TBD
Dept. Of Clinical Medicine, Aalborg University Hospital
Labtour - Ladegårdsgade (large animal facilities)
Dept. Of Clinical Medicine, Aalborg University Hospital
Coffe
Göttingen mini-pigs
Ellegaard Göttingen Minipigs
3R in animal research
Dept. of Clinical Medicine, Aarhus University
12.00-16.00
Time allocated for PhD students to complete assignment to pass the course activity
Organizers:
Professor Winnie Jensen, Associate Professor Suzan Meijs, Associate Professor Allan Steensballe, Assistant Professor Felipe Rettore Andreis
ECTS: 1.5
Important information concerning PhD courses: We have over some time experienced problems with no-show for both project and general courses. It has now reached a point where we are forced to take action. Therefore, the Doctoral School has decided to introduce a no-show fee of DKK 3000 for each course where the student does not show up. Cancellations are accepted no later than 2 weeks before start of the course. Registered illness is of course an acceptable reason for not showing up on those days. Furthermore, all courses open for registration approximately four months before start. This can hopefully also provide new students a chance to register for courses during the year. We look forward to your registration.