Description:
This PhD course will focus on the classic research strategies to obtain diagnostic as well as therapeutic improvements as the background for a paradigm shift from "one fits all" to individualized strategies in clinical practice.
The complex cancer biology model for oncogenesis will be presented documenting the importance of the translational approach for the future - requiring new multidisciplinary engagements. Based on highly selected lectures and papers, we will discuss novel, cutting edge technologies (Multiparametric Flow Cytometry and Cell Sorting, Microarray Technologies, Gene Sequencing, Biobanking), Cancer models (Cancer Cell Lines and Mice Models) and the future design of trials (treatment, diagnostics) and endpoints while adhering to scientific rigor when interpreting results and decisions.
The course will include lectures, workshops and journal clubs. The outcome for participants will be insight into new technologies and approaches allowing the future researchers to participate in the translation of scientific discoveries into cost-effective and meaningful clinical improvements in patient care.
Literature
1. “The Unwritten Rules of PhD Research” Marian Petre & Gordon Rugg Open University Press, 2010, 320pp, paperback, £19.99, ISBN 0 335 237029
2. Greaves M, Maley CC. Clonal evolution in cancer. Nature. 2012 Jan 18;481(7381):306-13.
3. Croce CM. Oncogenes and cancer. N Engl J Med. 2008 Jan 31;358(5):502-11.
4. Irish JM, Kotecha N, Nolan GP. Mapping normal and cancer cell signalling networks: towards single-cell proteomics. Nat Rev Cancer. 2006 Feb;6(2):146-55.
5. Valent P et al. Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer. 2012 Nov;12(11):767-75.
6. Barretina J et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012 Mar 28;483(7391):603-7.
7. Frese KK, Tuveson DA. Maximizing mouse cancer models. Nat Rev Cancer. 2007 Sep;7(9):645-58. Review. PubMed PMID: 17687385.
Prerequisites
Enrolled in a PhD program at a Danish University.
Evaluation
To pass the course, it is expected that the participants will attended all lectures and present and discuss 1) a priori given highly selected article on the course topic or 2) the status of her/his PhD project including hypothesis, aims and conclusions.
Organizer:
Professor H.E. Johnsen, Aalborg University Hospital, and The Clinical Cancer Research Center Aalborg University Hospital (CCRC-AUH)
Lecturers:
Professor H.E. Johnsen
Associate Professor K. Dybkær
Associate Professor M. Bøgsted
Cand Scient PhD J.S. Bødker
Cand Scient PhD A. Schmitz
Cand Scient PhD M.K. Kjeldsen, Aalborg University Hospital
and invited national/international lectures
ECTS:
3.0
Time:
November 12 (afternoon) 13, 14, 2013 (2½ days)
Place:
Klitgaarden Refugium
Zip code:
9900
City:
Skagen
Number of seats:
17
Deadline:
October 8, 2013
Important information concerning PhD courses
We have over some time experienced problems with no-show for both project and general courses. It has now reached a point where we are forced to take action. Therefore, the Doctoral School has decided to introduce a no-show fee of DKK 5,000 for each course where the student does not show up. Cancellations are accepted no later than 2 weeks before start of the course. Registered illness is of course an acceptable reason for not showing up on those days. Furthermore, all courses open for registration approximately three months before start. This can hopefully also provide new students a chance to register for courses during the year. We look forward to your registrations.
- Teacher: Hans E Johnsen